Bone mineral density does not improve with high-dose vitamin D therapy in a case of Loeys-Dietz syndrome 2 osteoporosis

* Hansjorg Rothe, Leipzig Dialysis Center, Mato Nagel, Weisswasser center of dialysis and metabolism
Poster Sessions, Presentation Number: LB SUN-826
Session: Poster Session: Late-Breaking II
Sunday, September 11, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

Col1a1^G643S/+ mouse model of osteogenesis imperfecta

* Shinji Takeyari, Department of Pediatrics, Osaka University Graduate School of Medicine, Yasuhisa Ohata, Department of Pediatrics, Osaka University Graduate School of Medicine, Makoto Fujiwara, Department of Pediatrics, Osaka University Graduate School of Medicine, Taichi Kitaoka, Department of Pediatrics, Osaka University Graduate School of Medicine, Takuo Kubota, Department of Pediatrics, Osaka University Graduate School of Medicine, Keiichi Ozono, Department of Pediatrics, Osaka University Graduate School of Medicine
Poster Session II, Presentation Number: SUN-723
Session: Poster Session II
Sunday, September 11, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

Cped1 impacts osteoblast mediated extracellular matrix production in an isoform specific manner.

* Cheryl L Ackert-Bicknell, Department of Orthopedics, University of Colorado, Kevin Schilling, Oregon Health & Science University, Dana A Godfrey, University of Colorado, Gregory Ottenberg, Department of Orthopedics, University of Colorado, Qian Liu, Nevada Institute of Personalized Medicine (NIPM) University of Nevada, Robert Maynard, University of Colorado
Poster Session II, Presentation Number: SUN-369
Session: Poster Session II
Sunday, September 11, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

De novo serine synthesis regulates osteoclast differentiation and bone homeostasis

* Steve Stegen, Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Karen Moermans, Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Ingrid Stockmans, Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Bernard Thienpont, Functional Epigenetics, Department of Human Genetics, Geert Carmeliet, Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven
Poster Session II, Presentation Number: SUN-416
Session: Poster Session II
Sunday, September 11, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

Orbit: A Randomized, Double-Blind, Placebo-controlled, Phase 2/3 Study to Assess the Efficacy and Safety of Setrusumab in Pediatric and Young Adult Participants with Osteogenesis Imperfecta

Nicholas Bishop, Department of Oncology and Metabolism, University of Sheffield , Eric Rush, Children's Mercy Kansas City; Department of Pediatrics, University of Missouri – Kansas City School of Medicine; Department of Internal Medicine, University of Kansas Medical Center, V Reid Sutton, Department of Molecular & Human Genetics, Baylor College of Medicine & Texas Children's Hospital , Luca Sangiorgi, Rizzoli Orthopaedic Institute, Oliver Semler, University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, Gary Gottesman, Divisions of Endocrinology and Diabetes, Genetics and Genomics Medicine, Bone and Mineral Diseases, Washington University School of Medicine, Arun Mistry, Mereo BioPharma, Alastair MacKinnon, Mereo BioPharma, Claudine Woo, Ultragenyx Pharmaceutical Inc., Hui Wang, Ultragenyx Pharmaceutical Inc., Wendy Putnam, Ultragenyx Pharmaceutical Inc., Antonio Nino Ramirez, Ultragenyx Pharmaceutical Inc., * Michael Ominski, Ultragenyx Pharmaceutical Inc.
Poster Sessions, Presentation Number: LB SAT-897
Session: Poster Session: Late-Breaking I
Saturday, September 10, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

Age-Associated Bone Loss is Accompanied by Decreased Osteocyte Tethering Elements and Altered Lacuno-canalicular Morphology

* Perla Reyes Fernandez, Department of Physical Therapy, School of Health and Human Sciences, Indiana University, Jennifer Coulombe, Department of Mechanical Engineering, University of Colorado, Virginia Ferguson, Department of Mechanical Engineering, University of Colorado, Katie Rust, Department of Physical Therapy, School of Health and Human Sciences, Indiana University, Shannon Modla, Delaware Biotechnology Institute, University of Delaware, Mary Farach-Carson, Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, William Thompson, Department of Physical Therapy, School of Health and Human Sciences, Indiana University
Poster Session II, Presentation Number: SUN-310
Session: Poster Session II
Sunday, September 11, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

Alkaline Phosphatase Is More Than a Pro-mineralizing Enzyme: Effecting Adipogenesis and Mitochondrial Function

* Victoria DeMambro, Maine Medical Center Research Institute, Jennifer Daruszka, Maine Medical Center Research Institute, Samantha Costa, Maine Medical Center Research Institute, Michael Whyte, Shriners Hospitals for Children – St. Louis, José Millán, Sanford Children's Health Research Center, Anyonya Guntur, Maine Medical Center Research Institute, Clifford Rosen, Maine Medical Center Research Institute
Poster Sessions, Presentation Number: FRI-697
Session: Welcome Reception and Plenary Poster Session
Friday, September 9, 2022 5:30 PM - 7:00 PM, Austin Convention Center, Exhibit Halls 3-4
Poster Session I, Presentation Number: SAT-697
Session: Poster Session I
Saturday, September 10, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

Copb2 Haploinsufficiency Leads to Low Bone Mass by Disrupting Collagen Secretion and Organization

* Ava Berrier, Baylor College of Medicine, Megan Washington , Baylor College of Medicine, I-Wen Song , Baylor College of Medicine , Vittoria Rossi, Baylor College of Medicine , Yuqing Chen, Baylor College of Medicine, Xiaohui Li, Baylor College of Medicine, Brian Dawson, Baylor College of Medicine , Joseph Sliepka , Baylor College of Medicine , Cole Kuzawa, McGovern Medical School, Lindsay Burrage , Baylor College of Medicine, Catherine Ambrose, McGovern Medical School, Brendan Lee, Baylor College of Medicine, Ronit Marom, Baylor College of Medicine
Poster Session II, Presentation Number: SUN-691
Session: Poster Session II
Sunday, September 11, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4

EFEMP1 Regulates Bone Structure and Affects Fracture Risk: A Discovery from HR-pQCT Bone Microarchitecture GWAS Screening Confirmed by CRISPR Knockout Zebrafishes and Mice: The Bone Microarchitecture International Consortium (BoMIC)

* Yi-Hsiang Hsu, HSL Marcus Institute for Aging Research, Harvard Medical School, Ronald Y Kwon, 8Orthopaedics and Sports Medicine, Univ. of Washington, Fredrick Kinyua, HSL Marcus Institute for Aging Research, Harvard Medical School, Andy Kin On Wong, Toronto General Research Institute, Univ. Health Network and McMaster Univ., Jyoti Rai, Orthopaedics and Sports Medicine, Univ. of Washington, John Hulleman, Ophthalmology, School of Pharmacology, UT Southwestern Medical Center, Claire Watson, Orthopaedics and Sports Medicine, Univ. of Washington, Paul Okoro, HSL Marcus Institute for Aging Research, Harvard Medical School, Ming-Ju Tsai, HSL Marcus Institute for Aging Research, Harvard Medical School, Maria Nethander, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, at the Sahlgrenska Academy, University of Gothenburg, , Tianyuan Lu, Lady Davis Institute and Depart. of Human Genetics, McGill Univ. , Marian Renwick, Ophthalmology, School of Pharmacology, UT Southwestern Medical Center, Andrew Burghardt, Univ. Of California, San Francisco, Shreyasee Amin, Mayo Clinic College of Med, Jonathan D. Adachi, Charlton Medical Centre, McMaster Univ, David Goltzman, Dept. of Medicine and Physiology, McGill Univ, David A. Hanley, Univ. of Calgary, Ching-Ti Liu, Boston Univ. Sch. of Public Health, David Karasik, HSL Marcus Institute for Aging Research, Harvard Medical School, Steven K. Boyd, Department of Radiology, Cumming School of Medicine, University of Calgary, Mary L. Bouxsein, Beth Israel Deaconess Medical Center, Harvard Medical School, Dan Mellström, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, at the Sahlgrenska Academy, University of Gothenburg, , Mattias Lorentzon, Sahlgrenska Osteoporosis Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Elisabeth Sornay-Rendu, National Institute of Health and Medical Research (INSERM) and Univ. of Lyon, Eric Lespessailles, Université Orleans, Brent Richards, Lady Davis Institute and Depart. of Human Genetics, McGill Univ. , Eric Orwoll, School of Medicine, Oregon Health & Science University, Serge Ferrari, Department of Medicine, University of Geneva, Sundeep Khosla, Mayo Clinic College of Med, Pawel Szulc, National Institute of Health and Medical Research (INSERM) and Univ. of Lyon, Roland D. Chapurlat, National Institute of Health and Medical Research (INSERM) and Univ. of Lyon, Claes Ohlsson, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, at the Sahlgrenska Academy, University of Gothenburg, , Douglas Kiel, HSL Marcus Institute for Aging Research, Harvard Medical School
Oral Presentations, Presentation Number: 1065
Session: Oral Presentations: Osteoporosis Therapy: Mechanisms of Action and Novel Targets
Sunday, September 11, 2022 4:15 PM - 4:30 PM, Austin Convention Center, Ballrooms E-F

Ifitm5/BRIL p.S42L murine model for atypical type VI OI has elevated serum alkaline phosphatase and disordered bone matrix but decreased bone cell function

* Gali Guterman-Ram, Section on Heritable Disorders of Bone and Extracellular Matrix, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Ghazal Hedjazi, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital,, Milena Jovanovic, Section on Heritable Disorders of Bone and Extracellular Matrix, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Chris Stephan, epartments of Orthopaedic Surgery and Biomedical Engineering, University of Michigan, Aileen Barnes, Section on Heritable Disorders of Bone and Extracellular Matrix, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Stéphane Blouin, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Victoria Schemenz, Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Markus A. Hartmann, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Theresa Hefferan, Mayo Clinic, Biomaterials and Histomorphometry Core Laboratory, Pamela G. Robey, Skeletal Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Peter Fratzl, Max Planck Institute of Colloids and Interfaces, Dept. of Biomaterials, Jochen Zwerina, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Kenneth M Kozloff, Departments of Orthopaedic Surgery and Biomedical Engineering, University of Michigan, Nadja Fratzl-Zelman, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Joan C Marini, Section on Heritable Disorders of Bone and Extracellular Matrix, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Poster Sessions, Presentation Number: FRI-702
Session: Welcome Reception and Plenary Poster Session
Friday, September 9, 2022 5:30 PM - 7:00 PM, Austin Convention Center, Exhibit Halls 3-4
Poster Session I, Presentation Number: SAT-702
Session: Poster Session I
Saturday, September 10, 2022 1:00 PM - 3:00 PM, Austin Convention Center, Exhibit Halls 3-4