Angiogenesis Inhibitors (AgIs) and Chemotherapy Drugs Associated with Osteonecrosis of the Jaw Exhibit In Vivo Anti-resorptive Activity

* Evelyn Castillo, University of Florida, Summer Croft, University of Florida, Gabriella Gonzalez-Perez, University of Florida, L. Shannon Holliday, University of Florida, Lorraine Perciliano de Faria, University of Florida, J. Ignacio Aguirre, University of Florida, Donald Kimmel, University of Florida
Poster Sessions, Presentation Number: P-835
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

Dio3os influences neighboring Dio3 gene expression and in trans regulates osteoblastogenesis

QUAMARUL HASSAN, School of Dentistry, University of Alabama, * Yuechuan Chen, School of Dentistry, University of Alabama, Birmingham AL, Benjamin Wildman, School of Dentistry, University of Alabama, Delores Stacks, School of Dentistry, University of Alabama, Mohammad Rehan, School of Dentistry, University of Alabama
Poster Sessions, Presentation Number: P-420
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

Gprc5a is a novel target gene of teriparatide involved in osteoblastic cell proliferation.

* Kosuke Kato, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yasuhiro Arasaki, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, Tokyo University of Science, Takuro Akiya, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, Tokyo University of Science, Masaki Noda, Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical & Dental University (TMDU), Yoichi Ezura, Department of Judo Therapy, Faculty of Medical Technology, Teikyo University, Tadayoshi Hayata, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, Tokyo University of Science
Poster Sessions, Presentation Number: P-432
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

In Vitro Osteoclast Assay as a Predictor of Zoledronate Response In Vivo

* Jukka Rissanen, Pharmatest Services, Katja Fagerlund, Pharmatest Services, ZhiQi Peng, Pharmatest Services, Jukka Morko, Pharmatest Services
Poster Sessions, Presentation Number: P-738
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

The Role of Pre-existing Infection/Inflammation and Oncology Doses of Zoledronic Acid in the Development of Osteonecrosis of the Jaw after Tooth Extraction in Rice Rats

* Evelyn Castillo, University of Florida, Abel Abraham, University of Florida, Summer Croft, University of Florida, Gabriella Gonzalez-Perez, University of Florida, Jessica Jiron, University of Florida, Samantha Thomas, University of Florida, Indraneel Bhattacharyya, University of Florida, Donald Kimmel, University of Florida, J. Ignacio Aguirre, University of Florida
Poster Sessions, Presentation Number: P-751
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

Dyrk1a-Related Down Syndrome Bone Defects Abrogated by Temporally-Targeted Pharmacological Intervention

* Jonathan LaCombe, IUPUI, Matthew Blackwell, IUPUI, Kourtney Sloan, IUPUI, Randall Roper, IUPUI
Poster Sessions, Presentation Number: P-710
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

Effect of Parathyroid Hormone (1-34) on Gross ONJ-like Lesions in Rice Rats Treated with Oncology Doses of Zoledronic Acid

* Evelyn Castillo, University of Florida, Jessica Jiron, University of Florida, Gabriella Gonzalez-Perez, University of Florida, Samantha Thomas, University of Florida, Summer Croft, University of Florida, Indraneel Bhattacharyya, University of Florida, Donald Kimmel, University of Florida, J. Ignacio Aguirre, University of Florida
Poster Sessions, Presentation Number: P-830
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

Gnas heterozygous inactivation in a mouse model of Albright hereditary osteodystrophy differentially affects cortical bone formation based upon parental inheritance of mutation

* Patrick McMullan, Depts of Pediatrics and Center for Regenerative Medicine and Skeletal Development, UConn Health, Peter Maye, Center for Regenerative Medicine and Skeletal Development, UConn Health, David Rowe, Center for Regenerative Medicine and Skeletal Development, UConn Health, Emily Germain-Lee, Depts of Pediatrics and Center for Regenerative Medicine and Skeletal Development, UConn Health and Division of Pediatric Endocrinology, Connecticut Children’s
Poster Sessions, Presentation Number: P-808
Session: Plenary Poster Presentation
Friday, September 11, 2020 10:00 AM - 4:00 PM

GNAS product XLαs, but not Gsα, exhibits variable allele-specific expression in bone marrow stromal samples: “next-generation” sequencing (NGS) to determine parental contribution.

* Qiuxia Cui, Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School; Zhongnan Hospital, Wuhan University, Claire Elizabeth Remillard, Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Antonius Plagge, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Mina Gardezi, Department of Orthopaedic Surgery, Boston University School of Medicine, Margret Dunlap, Department of Orthopaedic Surgery, Boston University School of Medicine, Louis C Gerstenfeld, Department of Orthopaedic Surgery, Boston University School of Medicine, Qing He, Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School; School of Stomatology, Wuhan University, Murat Bastepe, Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School
Poster Sessions, Presentation Number: P-154
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM

High-throughput cathelicidin bioassay utilizing HiTCA, a novel CRISPR Cas9-edited human monocytic cell line

* Carter Gottlieb, Department of Orthopaedic Surgery, Orthopaedic Hosital Research Center, UCLA , Rene Chun, Department of Orthopaedic Surgery, Orthopaedic Hosital Research Center, UCLA, Jeffrey Wang, Department of Orthopaedic Surgery, Orthopaedic Hosital Research Center, UCLA, Vahe Yacoubian, Department of Orthopaedic Surgery, Orthopaedic Hosital Research Center, UCLA, John S Adams, Department of Orthopaedic Surgery, Orthopaedic Hosital Research Center, UCLA
Poster Sessions, Presentation Number: P-137
Session: Poster Presentations
Friday, September 11, 2020 10:00 AM - 4:00 PM